Literature summary for 7.2.2.13 extracted from

Farias, D.L.; Lucena, M.N.; Garcon, D.P.; Mantelatto, F.L.; McNamara, J.C.; Leone, F.A.
A kinetic characterization of the gill (Na+, K+)-ATPase from the semi-terrestrial mangrove crab Cardisoma guanhumi Latreille, 1825 (Decapoda, Brachyura) (2017), J. Membr. Biol., 250, 517-534 .

Search for more literature for 7.2.2.13

Inhibitors

Inhibitors	Comment	Organism	Structure
orthovanadate	increasing orthovanadate concentrations from 0.0001 mM to 1 mM inhibit total ATPase activity by around 75%	Cardisoma guanhumi
Ouabain	76.4% residual activity at 3 mM	Cardisoma guanhumi

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.05	-	ATP	at pH 7.5 and 25°C	Cardisoma guanhumi

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Cardisoma guanhumi	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required in form of MgATP. At low Mg2+ concentrations, ATP is an allosteric modulator of the enzyme	Cardisoma guanhumi

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Na+[side 1] + K+[side 2]	Cardisoma guanhumi	-	ADP + phosphate + Na+[side 2] + K+[side 1]	-	?

Organism

Organism	UniProt	Comment	Textmining
Cardisoma guanhumi	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gill	-	Cardisoma guanhumi	-
gill	in the apical region of the epithelial pillar cells, and throughout the pillar cell bodies	Cardisoma guanhumi	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Na+[side 1] + K+[side 2]	-	Cardisoma guanhumi	ADP + phosphate + Na+[side 2] + K+[side 1]	-	?

Subunits

Subunits	Comment	Organism
?	x * 110000, SDS-PAGE	Cardisoma guanhumi

Synonyms

Synonyms	Comment	Organism
(Na+, K+)-ATPase	-	Cardisoma guanhumi

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.001	-	orthovanadate	at pH 7.5 and 25°C	Cardisoma guanhumi
0.052	-	Ouabain	at pH 7.5 and 25°C	Cardisoma guanhumi

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Release 2023.1 (January 2023)