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Literature summary for 7.2.2.13 extracted from

  • Botta, P.; de Souza, F.M.; Sangrey, T.; De Schutter, E.; Valenzuela, C.F.
    Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase (2010), Neuropsychopharmacology, 35, 1984-1996.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
ethanol inhibits the enzyme in Golgi membranes of cerebellar neurons leading to potentiation of GABAergic transmission at Golgi cell-to-granule cell synapses throughan increase in Golgi cell excitability Rattus norvegicus
Ouabain
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane
-
 Rattus norvegicus 139
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Rattus norvegicus modelling of enzyme function in neurons in absence or presence of ethanol, overview ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Spargue-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Rattus norvegicus
-
granule cell of the input layer of cerebellar cortex Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out modelling of enzyme function in neurons in absence or presence of ethanol, overview Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+/K+ ATPase
-
 Rattus norvegicus

General Information

General Information Comment Organism
additional information ethanol-induced Na+,K+-ATPase inhibition leads to cerebellar dysfunction causing motor coordination impairments and cognitive deficits, and may also contribute to neuronal function alterations in other brain regions, overview. Ethanol increases firing frequency and regularity of spontaneous firing in presence of neurotransmitter receptor antagonists, ethanol increases spontaneous firing frequency and depolarizes the membrane potential, overview Rattus norvegicus