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Literature summary for 7.2.2.10 extracted from

  • Sanchez, G.A.; Takara, D.; Alonso, G.L.
    Local anesthetics inhibit Ca-ATPase in masticatory muscles (2010), J. Dent. Res., 89, 372-377.
    View publication on PubMed
Search for more literature for 7.2.2.10

Inhibitors

Inhibitors Comment Organism Structure
bupivacaine inhibition by bupivacaine is not competitive with respect to the specific transport and catalytic sites of the enzyme Oryctolagus cuniculus
lidocaine inhibition by lidocaine is not competitive with respect to the specific transport and catalytic sites of the enzyme Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcoplasmic reticulum membrane
-
 Oryctolagus cuniculus 33017
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+/cis Oryctolagus cuniculus sarcoplasmic reticulum Ca-ATPase transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis ADP + phosphate + Ca2+/trans
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 adult New Zealand rabbits
-

Purification (Commentary)

Purification (Comment) Organism
partially by preparation of sarcoplasmic reticulum vesicles Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
masticatory muscle masseter and medial pterygoid Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/cis sarcoplasmic reticulum Ca-ATPase transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis Oryctolagus cuniculus ADP + phosphate + Ca2+/trans
-
 ?
ATP + H2O + Ca2+/cis the enzyme has one high affinity ATP binding site (catalytic site) and two calcium-binding sites Oryctolagus cuniculus ADP + phosphate + Ca2+/trans
-
 ?

Synonyms

Synonyms Comment Organism
Ca-ATPase
-
 Oryctolagus cuniculus
sarcoplasmic reticulum Ca-ATPase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibitory potencies of narcotic substances on Ca2+-ATPase activity in masticatory muscles, masseter and medial pterygoid, overview Oryctolagus cuniculus

General Information

General Information Comment Organism
physiological function sarcoplasmic reticulum Ca-ATPase is a membrane-bound protein which transports calcium ions from the myoplasm to the reticulum lumen at the expense of ATP hydrolysis, leading to muscle relaxation Oryctolagus cuniculus