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Literature summary for 7.2.2.10 extracted from

  • Xiang, M.; Mohamalawari, D.; Rao, R.
    A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain (2005), J. Biol. Chem., 280, 11608-11614.
    View publication on PubMed
Search for more literature for 7.2.2.10

Cloned(Commentary)

Cloned (Comment) Organism
gene ATP2C2, isozyme SPCA2, DNA and amino acid sequence determination and analysis, expression in Mn2+-sensitive pmr1 null mutant strain K616 of Saccharomyces cerevisiae, isozyme SPCA2 complements better than isozyme SPCA1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus isozyme SPCA2 Homo sapiens 5794
-
membrane isozymes SPCA1 and SPCA2 Homo sapiens 16020
-
perinuclear space isozyme SPCA1 Homo sapiens
-
-
secretory vesicle from the trans-Golgi network, isozyme SPCA2 Homo sapiens 99503
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ isozyme SPCA1 shows the Ca2+-preferring phenotype Homo sapiens
Mg2+ required for ATPase activity Homo sapiens
Mn2+ isozyme SPCA2 shows the Mn2+-preferring phenotype Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+/cis Homo sapiens Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities ADP + phosphate + Ca2+/trans
-
 ?
additional information Homo sapiens the Ca2+,Mn2+-ATPase SPCA2 is involved in the secretory pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes SPCA1 and SPCA2, genes ATP2C1 and ATP2C2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme SPCA2 Homo sapiens
-
keratinocyte and nonpolarized cells, isozyme SPCA1 Homo sapiens
-
additional information isozyme SPCA1 shows a less limited tissue distribution than isozyme SPCA2 Homo sapiens
-
neuronal cell primary, isozyme SPCA2 shows a highly punctate distribution Homo sapiens
-
testis isozyme SPCA2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/cis Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities Homo sapiens ADP + phosphate + Ca2+/trans
-
 ?
additional information the Ca2+,Mn2+-ATPase SPCA2 is involved in the secretory pathway Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+,Mn2+-ATPase
-
 Homo sapiens
SPCA1
-
 Homo sapiens
SPCA2
-
 Homo sapiens