Literature summary for 7.2.2.10 extracted from

Tupling, A.R.; Gramolini, A.O.; Duhamel, T.A.; Kondo, H.; Asahi, M.; Tsuchiya, S.C.; Borrelli, M.J.; Lepock, J.R.; Otsu, K.; Hori, M.; MacLennan, D.H.; Green, H.J.
HSP70 binds to the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1a) and prevents thermal inactivation (2004), J. Biol. Chem., 279, 52382-52389.

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Activating Compound

Activating Compound	Comment	Organism	Structure
HSP70	chaperone system can bind to enzyme and, depending on the severity of heat stress, protect the enzyme's function by stabilizing the nucleotide binding domain	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
transfection in HEK-293 cells	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
sarcoplasmic reticulum	-	Rattus norvegicus	16529	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gastrocnemius	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
SERCA1a	-	Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
additional information	-	the maximal activity is reduced progressively with increasing temperature and time of incubation	Rattus norvegicus

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Release 2023.1 (January 2023)