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Literature summary for 7.2.2.10 extracted from
- Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses (2002), J. Biol. Chem., 277, 45579-45591.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
| Ca2+ | - |
Oryctolagus cuniculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isoforms 3a, b and c, transfection in HEK-293 or COS-1 cells using the calcium phosphate precipitation method | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| vanadate | - |
Homo sapiens | |
| vanadate | - |
Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
Ca2+ | - |
Oryctolagus cuniculus | |
| 0.0013 | - |
Ca2+ | isoform3b | Homo sapiens | |
| 0.0017 | - |
Ca2+ | isoform3a | Homo sapiens | |
| 0.0018 | - |
Ca2+ | isoform3c | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | Homo sapiens | - |
ADP + phosphate + Ca2+/trans | - |
? | |
| ATP + H2O + Ca2+/cis | Oryctolagus cuniculus | - |
ADP + phosphate + Ca2+/trans | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | - |
Homo sapiens | ADP + phosphate + Ca2+/trans | - |
? | |
| ATP + H2O + Ca2+/cis | - |
Oryctolagus cuniculus | ADP + phosphate + Ca2+/trans | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SERCA1 | - |
Oryctolagus cuniculus |
| SERCA3 | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 90 | - |
Ca2+ | isoform 3c in presence of a saturing Ca2+ at pH 7.0, in presence of ionophore | Homo sapiens | |
| 95 | - |
Ca2+ | in presence of 0.1 mM Ca2+ at pH optimum 7.23, in presence of ionophore | Oryctolagus cuniculus | |
| 98 | - |
Ca2+ | isoform 3a in presence of a saturing Ca2+ concentration at pH 7.0, in presence of ionophore | Homo sapiens | |
| 100 | - |
Ca2+ | isoform 3b in presence of a saturing Ca2+ at pH 7.0, in presence of ionophore | Homo sapiens | |
| 128 | - |
Ca2+ | in presence of a saturing Ca2+ at pH 7.0, in presence of ionophore | Oryctolagus cuniculus | |
| 132 | - |
Ca2+ | isoform 3a in presence of 0.1 mM Ca2+ at pH optimum 7.72, in presence of ionophore | Homo sapiens | |
| 134 | - |
Ca2+ | isoform 3c in presence of 0.1 mM Ca2+ at pH optimum 7.78, in presence of ionophore | Homo sapiens | |
| 149 | - |
Ca2+ | isoform 3b in presence of 0.1 mM Ca2+ at pH optimum 7.74, in presence of ionophore | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.23 | - |
in presence of Ca2+ ionophore | Oryctolagus cuniculus |
| 7.7 | 8 | isoform 3c in presence of Ca2+ ionophore | Homo sapiens |
| 7.72 | - |
isoform 3a in presence of Ca2+ ionophore | Homo sapiens |
| 7.74 | - |
isoform 3b in presence of Ca2+ ionophore | Homo sapiens |
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