Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-galactono-gamma-lactone | - |
Mus musculus | |
L-galactono-gamma-lactone | - |
Homo sapiens | |
L-galactono-gamma-lactone | - |
Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in a Saccharomyces cerevisiae strain S288C DELTAfre1DELTAfre2 mutant, which lacks almost all of its plasma membrane ferrireductase activity | Mus musculus |
expressed in a Saccharomyces cerevisiae strain S288C DELTAfre1DELTAfre2 mutant, which lacks almost all of its plasma membrane ferrireductase activity | Homo sapiens |
expressed in a Saccharomyces cerevisiae strain S288C DELTAfre1DELTAfre2 mutant, which lacks almost all of its plasma membrane ferrireductase activity | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
D38A | the mutant shows increased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
E117A | the mutant shows decreased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
E196A | the mutant shows decreased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
F44A | the mutation reduces the Fe(CN)3 reductase activity by about 45% | Mus musculus |
H105A | the mutant shows increased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
H112A | the mutant shows decreased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
H117A | the mutation completely abrogates the Fe(CN)3 reductase activity of the enzyme | Mus musculus |
H156A | the mutation completely abrogates the Fe(CN)3 reductase activity of the enzyme | Mus musculus |
H47A | the mutation completely abrogates the Fe(CN)3 reductase activity of the enzyme | Mus musculus |
H83A | the mutation completely abrogates the Fe(CN)3 reductase activity of the enzyme | Mus musculus |
M51A | the mutant shows increased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
N106A | the mutant shows increased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
P48A | the mutant shows increased reductase activity compared to the wild type enzyme | Mus musculus |
Q131A | the activity of the mutant is reduced significantly to 45% of that of the wild type | Mus musculus |
R149A | the mutation results in a 75% loss in activity compared to the wild type enzyme | Mus musculus |
R67A | the mutation results in an almost complete loss of the Fe(CN)3 reductase activity | Mus musculus |
S115A | the ferrireductase activity in the mutant is reduced to 50% | Mus musculus |
W119A | the ferrireductase activity in the mutant is reduced to 17% | Mus musculus |
W119A | the mutant shows decreased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
Y190A | the mutant shows increased Fe(CN)3 reductase activity compared to the wild type enzyme | Mus musculus |
Y66A | the mutation results in an almost complete loss of the Fe(CN)3 reductase activity | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromaffin granule | - |
Mus musculus | 42583 | - |
chromaffin granule | - |
Homo sapiens | 42583 | - |
chromaffin granule | - |
Rattus norvegicus | 42583 | - |
lysosome | - |
Mus musculus | 5764 | - |
lysosome | - |
Homo sapiens | 5764 | - |
lysosome | - |
Rattus norvegicus | 5764 | - |
plasma membrane | - |
Mus musculus | 5886 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
LCytb, SDS-PAGE | Mus musculus |
27800 | - |
CGCytb, SDS-PAGE | Mus musculus |
31500 | - |
DCytb, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
duodenum | - |
Mus musculus | - |
duodenum | - |
Homo sapiens | - |
duodenum | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ascorbate[side 1] + Fe(CN)3[side 2] | - |
Mus musculus | monodehydroascorbate[side 1] + ? | - |
? | |
ascorbate[side 1] + Fe(CN)3[side 2] | - |
Homo sapiens | monodehydroascorbate[side 1] + ? | - |
? | |
ascorbate[side 1] + Fe(CN)3[side 2] | - |
Rattus norvegicus | monodehydroascorbate[side 1] + ? | - |
? | |
ascorbate[side 1] + Fe3+-EDTA[side 2] | - |
Mus musculus | monodehydroascorbate[side 1] + ? | - |
? | |
ascorbate[side 1] + Fe3+-EDTA[side 2] | - |
Homo sapiens | monodehydroascorbate[side 1] + ? | - |
? | |
ascorbate[side 1] + Fe3+-EDTA[side 2] | - |
Rattus norvegicus | monodehydroascorbate[side 1] + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ascorbate-dependent ferrireductase | - |
Mus musculus |
ascorbate-dependent ferrireductase | - |
Homo sapiens |
ascorbate-dependent ferrireductase | - |
Rattus norvegicus |
CGCytb | - |
Mus musculus |
CGCytb | - |
Homo sapiens |
CGCytb | - |
Rattus norvegicus |
chromaffin granule cytochrome b | - |
Mus musculus |
chromaffin granule cytochrome b | - |
Homo sapiens |
chromaffin granule cytochrome b | - |
Rattus norvegicus |
Cyt b561 | - |
Mus musculus |
Cyt b561 | - |
Homo sapiens |
Cyt b561 | - |
Rattus norvegicus |
DCytb | - |
Mus musculus |
DCytb | - |
Homo sapiens |
duodenal cytochrome b | - |
Mus musculus |
duodenal cytochrome b | - |
Homo sapiens |
LCytb | - |
Mus musculus |
LCytb | - |
Homo sapiens |
LCytb | - |
Rattus norvegicus |
lysosomal cytochrome b | - |
Mus musculus |
lysosomal cytochrome b | - |
Homo sapiens |
lysosomal cytochrome b | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | dependent on | Mus musculus | |
ascorbate | dependent on | Homo sapiens | |
ascorbate | dependent on | Rattus norvegicus |