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Literature summary for 7.1.1.9 extracted from

  • Ren, J.C.; Rebrin, I.; Klichko, V.; Orr, W.C.; Sohal, R.S.
    Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster (2010), Biochem. Biophys. Res. Commun., 401, 64-68.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ferricytochrome c + H2O Drosophila melanogaster
-
 ferrocytochrome c + O2 + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle thoracic flight muscle Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferricytochrome c + H2O
-
 Drosophila melanogaster ferrocytochrome c + O2 + H+
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
CCO
-
 Drosophila melanogaster
cytochrome c oxidase
-
 Drosophila melanogaster
ferrocytochrome c:oxygen oxidoreductase
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
heme
-
 Drosophila melanogaster

Expression

Organism Comment Expression
Drosophila melanogaster enzyme activity declines progressively with age between 10 and 47 days by 33% down

General Information

General Information Comment Organism
physiological function the enzyme is a specific intra-mitochondrial site of age-related deterioration, which has a broad impact on mitochondrial physiology. The decline in enzyme activity during aging is associated with selective losses in the levels of both nuclear and mitochondrial DNA-encoded enzyme subunits Drosophila melanogaster