Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cystine | - |
Escherichia coli | |
Sulfide | inhibition is fully reversible; low-micromolar levels of sulfide directly inhibit the proton-pumping cytochrome bo oxidase, but not cytochrome bd oxidase | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquinol + O2 + H+[side 1] | Escherichia coli | - |
ubiquinone + H2O + H+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli | P0ABJ1 and P0ABI8 and P0ABJ3 and P0ABJ6 | P0ABJ1 i.e. subunit cyoA, P0ABI8 i.e. subunit cyoB, P0ABJ3 i.e. subunit cyoC, P0ABJ6 i.e. subunit cyoD | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquinol + O2 + H+[side 1] | - |
Escherichia coli | ubiquinone + H2O + H+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytochrome bd oxidase | - |
Escherichia coli |
cytochrome bo oxidase | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | - |
cytochrome bo oxidase, at pH 7.0 and 25°C | Escherichia coli | Sulfide |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide | Escherichia coli |
physiological function | when cystine is provided and sulfide levels rise, Escherichia coli becomes strictly dependent upon cytochrome bd oxidase for continued respiration. Low-micromolar levels of sulfide inhibit the proton-pumping cytochrome bo oxidase. In the absence of the back-up cytochrome bd oxidase, growth fails. Exogenous sulfide elicits the same effect | Escherichia coli |