Literature summary for 7.1.1.1 extracted from

Francisco, A.; Ronchi, J.A.; Navarro, C.D.C.; Figueira, T.R.; Castilho, R.F.
Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet (2018), J. Neurochem., 147, 663-677 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61941	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	in a congenic mouse model carrying a mutated NNT gene, the absence of NNT activity results in lower total NADPH sources activity in the brain mitochondria of young mice, which is partially compensated in aged mice. Nonsynaptic mitochondria show higher NNT activity than synaptic mitochondria. In the absence of NNT, an increased release of H2O2 from mitochondria is observed when the metabolism of respiratory substrates occurs with restricted flux through relevant mitochondrial NADPH sources or when respiratory complex I is inhibited. Mitochondria from Nnt-/- brains are unable to sustain NADP in its reduced state when energized in the absence of carbon substrates	Mus musculus

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Release 2023.1 (January 2023)