Literature summary for 7.1.1.1 extracted from

Cabulong, R.B.; Valdehuesa, K.N.G.; Banares, A.B.; Ramos, K.R.M.; Nisola, G.M.; Lee, W.K.; Chung, W.J.
Improved cell growth and biosynthesis of glycolic acid by overexpression of membrane-bound pyridine nucleotide transhydrogenase (2019), J. Ind. Microbiol. Biotechnol., 46, 159-169 .

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Application

Application	Comment	Organism
synthesis	overexpression of pyridine nucleotide transhydrogenase, PntAB, results in a significant increase in biomass and glycolic acid titer and yield. Improved redox homeostasis resulting from PntAB overexpression positively affects the anabolic rate of the cell. PntAB overexpression result in 154 and 37% increase in NAD+/NADH ratio, at 48 and 72 h, respectively, while the the NADP+ concentrations are 70 and 30% lower at 24 and 72 h. Expression of PntAB in an optimized glycolic acid-producing strain improves the growth and product titer significantly	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Escherichia coli	16020	-

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P07001 and P0AB67	P07001 i.e. subunit PntA, P0AB67 i.e. subunit PntB	-

Synonyms

Synonyms	Comment	Organism
pntA	-	Escherichia coli
pntB	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	overexpression of pyridine nucleotide transhydrogenase, PntAB, results in a significant increase in biomass and glycolic acid titer and yield. Improved redox homeostasis resulting from PntAB overexpression positively affects the anabolic rate of the cell. PntAB overexpression result in 154 and 37% increase in NAD+/NADH ratio, at 48 and 72 h, respectively, while the NADP+ concentrations are 70 and 30% lower at 24 and 72 h. Expression of PntAB in an optimized glycolic acid-producing strain improves the growth and product titer significantly	Escherichia coli

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Release 2023.1 (January 2023)