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Literature summary for 7.1.1.1 extracted from

  • Favia, M.; Atlante, A.
    Cellular redox state acts as switch to determine the direction of NNT-catalyzed reaction in cystic fibrosis cells (2021), Int. J. Mol. Sci., 22, 967 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine NNT activity is about 30% lower in cystic fibrosis cells than healthy cells. The cellular redox state, together with the low mitochondrial membrane potential, pushes to drive NNT reverse reaction, at the expense of its antioxidant potential, thus consuming NADPH to support NADH production. At the same time, the reduced NNT activity prevents the NADH, produced by the reaction, from causing an explosion of ROS by the damaged respiratory chain, in accordance with the reduced level of mitochondrial ROS in NNT-loss cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q13423
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Source Tissue

Source Tissue Comment Organism Textmining
CFBE41o- cell
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 Homo sapiens
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