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Literature summary for 7.1.1.1 extracted from

  • Saeed, S.; Tremp, A.Z.; Sharma, V.; Lasonder, E.; Dessens, J.T.
    NAD(P) transhydrogenase has vital non-mitochondrial functions in malaria parasite transmission (2020), EMBO Rep., 21, e47832 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
crystalloid
-
 Plasmodium berghei 44312
-
membrane
-
 Plasmodium berghei 16020
-

Organism

Organism UniProt Comment Textmining
Plasmodium berghei A0A509AS70
-
-

Synonyms

Synonyms Comment Organism
PBANKA_1317200
-
 Plasmodium berghei

General Information

General Information Comment Organism
physiological function NTH has an essential structural role in crystalloid biogenesis, whilst its enzymatic activity is required for sporozoite development. An enzyme null mutant develops normally in the mouse. NTH-KO parasites display normal gametocyte development, gametogenesis, and form ookinetes of normal size and shape. Pigment in these ookinetes is more dispersed and not found in clusters that surround and highlight the crystalloids. Absence of these pigment clusters is caused by loss of crystalloid formation. NTH-KO parasites developed oocyst numbers comparable to wild-type, but these oocysts fail to produce sporozoites Plasmodium berghei