Literature summary for 7.1.1.1 extracted from

McCambridge, G.; Agrawal, M.; Keady, A.; Kern, P.; Hasturk, H.; Nikolajczyk, B.; Bharath, L.
Saturated fatty acid activates T cell inflammation through a nicotinamide nucleotide transhydrogenase (Nnt)-dependent mechanism (2019), Biomolecules, 9, 79 .

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Application

Application	Comment	Organism
medicine	in peripheral blood mononuclear cells, palmitate decreases immune cell expression of NNT, NADPH, and anti-oxidant glutathione, but increases reactive oxygen and proinflammatory Th17 cytokines. Oleate has no effect on these outcomes. Genetic inhibition of NNT recapitulates the effects of palmitate. Peripheral blood mononuclear cells from obese (BMI >30) compared to lean subjects have lower NNT and glutathione expression, and higher Th17 cytokine expression, none of which are changed by exogenous palmitate	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13423	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
peripheral blood mononuclear cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	peripheral blood mononuclear cells from obese (BMI >30) compared to lean subjects have lower NNT and glutathione expression	down

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Release 2023.1 (January 2023)