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Literature summary for 7.1.1.1 extracted from

  • Figueira, T.; Francisco, A.; Ronchi, J.; dos Santos, G.; Santos, W.; Treberg, J.; Castilho, R.
    NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria (2021), Arch. Biochem. Biophys., 707, 108934 .
    View publication on PubMed
Search for more literature for 7.1.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Mus musculus 5739
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Organism

Organism UniProt Comment Textmining
Mus musculus Q61941
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Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
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 Mus musculus
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General Information

General Information Comment Organism
physiological function presence of NNT function is observed in detergent-solubilized and intact functional skeletal muscle mitochondria isolated from wild-type (NNT+/+) mice, but not in skeletal muscle mitochondria from congenic mice carrying a mutated NNT gene (NNT-/-). The NADPH supplied by NNT supports up to 600 pmol/mg/min of H2O2 removal under selected conditions. Skeletal muscle mitochondria from NNT-/- mice remove exogenous H2O2 at wild-type levels and exhibit a maintained or even decreased net emission of endogenous H2O2 when substrates that support Krebs cycle reactions are present (e.g., pyruvate plus malate or palmitoylcarnitine plus malate). The total activities of concurrent NADP+-reducing enzymes such as IDH2, malic enzymes and glutamate dehydrogenase are about 70% elevated in NNT mice. Respiratory rates are similar between skeletal muscle mitochondria from both NNT genotypes Mus musculus