Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | - |
Staphylococcus aureus | |
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | - |
Streptococcus pneumoniae | |
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile | - |
Haemophilus influenzae | |
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile | - |
Staphylococcus aureus | |
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile | - |
Streptococcus pneumoniae | |
2-(butylsulfanyl)-5-hydroadenosine | - |
Haemophilus influenzae | |
2-amino-6,7-dimethoxyquinoline-3-carboxamide | - |
Haemophilus influenzae | |
2-amino-6,7-dimethoxyquinoline-3-carboxamide | - |
Staphylococcus aureus | |
2-amino-6,7-dimethoxyquinoline-3-carboxamide | - |
Streptococcus pneumoniae | |
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide | - |
Haemophilus influenzae | |
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide | - |
Staphylococcus aureus | |
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide | - |
Streptococcus pneumoniae | |
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide | - |
Haemophilus influenzae | |
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide | - |
Staphylococcus aureus | |
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide | - |
Streptococcus pneumoniae | |
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine | - |
Haemophilus influenzae | |
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine | - |
Staphylococcus aureus | |
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine | - |
Streptococcus pneumoniae | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide | - |
Haemophilus influenzae | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide | - |
Staphylococcus aureus | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide | - |
Streptococcus pneumoniae | |
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide | - |
Haemophilus influenzae | |
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide | - |
Staphylococcus aureus | |
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide | - |
Streptococcus pneumoniae | |
8-hydroxyquinoline-2-carboxylic acid | - |
Haemophilus influenzae | |
8-hydroxyquinoline-2-carboxylic acid | - |
Staphylococcus aureus | |
8-hydroxyquinoline-2-carboxylic acid | - |
Streptococcus pneumoniae | |
8-methoxy-2,3-dimethylquinoxalin-5-ol | - |
Haemophilus influenzae | |
8-methoxy-2,3-dimethylquinoxalin-5-ol | - |
Staphylococcus aureus | |
8-methoxy-2,3-dimethylquinoxalin-5-ol | - |
Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Staphylococcus aureus | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Streptococcus pneumoniae | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Haemophilus influenzae | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Streptococcus pneumoniae ATCC 10813 | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Staphylococcus aureus ATCC 29213 | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | P43813 | - |
- |
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus ATCC 29213 | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae ATCC 10813 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Staphylococcus aureus | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Streptococcus pneumoniae | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Haemophilus influenzae | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Streptococcus pneumoniae ATCC 10813 | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Staphylococcus aureus ATCC 29213 | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LigA | - |
Staphylococcus aureus |
LigA | - |
Streptococcus pneumoniae |
LigA | - |
Haemophilus influenzae |
NAD+-dependent DNA ligase | - |
Staphylococcus aureus |
NAD+-dependent DNA ligase | - |
Streptococcus pneumoniae |
NAD+-dependent DNA ligase | - |
Haemophilus influenzae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Staphylococcus aureus | |
NAD+ | - |
Streptococcus pneumoniae | |
NAD+ | - |
Haemophilus influenzae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide | |
0.000021 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile | |
0.000035 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile | |
0.000067 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide | |
0.0001 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide | |
0.0001 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide | |
0.000107 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide | |
0.00024 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide | |
0.000507 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | (2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | |
0.002 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile | |
0.0028 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide | |
0.003 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide | |
0.005 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 2-amino-6,7-dimethoxyquinoline-3-carboxamide | |
0.018 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine | |
0.025 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine | |
0.028 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide | |
0.061 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide | |
0.076 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 2-amino-6,7-dimethoxyquinoline-3-carboxamide | |
0.081 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 2-(butylsulfanyl)-5-hydroadenosine | |
0.094 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide | |
0.13 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | (2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | |
0.2 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 2-amino-6,7-dimethoxyquinoline-3-carboxamide | |
0.32 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 8-methoxy-2,3-dimethylquinoxalin-5-ol | |
0.425 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 8-hydroxyquinoline-2-carboxylic acid | |
0.447 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 8-hydroxyquinoline-2-carboxylic acid | |
0.5 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide | |
0.61 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 8-hydroxyquinoline-2-carboxylic acid | |
0.767 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine | |
1.31 | - |
pH and temperature not specified in the publication | Haemophilus influenzae | 8-methoxy-2,3-dimethylquinoxalin-5-ol |