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Literature summary for 6.5.1.2 extracted from

  • Shapiro, A.B.
    Complete steady-state rate equation for DNA ligase and its use for measuring product kinetic parameters of NAD+-dependent DNA ligase from Haemophilus influenzae (2014), BMC Res. Notes, 7, 287 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.2

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
 Haemophilus influenzae
nicotinamide mononucleotide
-
 Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haemophilus influenzae
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Haemophilus influenzae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

Synonyms Comment Organism
LigA
-
 Haemophilus influenzae
NAD+-dependent DNA ligase
-
 Haemophilus influenzae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Haemophilus influenzae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000032
-
 AMP pH and temperature not specified in the publication Haemophilus influenzae
0.000066
-
 nicotinamide mononucleotide pH and temperature not specified in the publication Haemophilus influenzae