Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta cells | Wolbachia sp. subsp. Brugia malayi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | - |
Wolbachia sp. subsp. Brugia malayi | |
1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one | - |
Wolbachia sp. subsp. Brugia malayi | |
1,6-bis(4-bromophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | - |
Wolbachia sp. subsp. Brugia malayi | |
1,6-bis(4-fluorophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | - |
Wolbachia sp. subsp. Brugia malayi | |
1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | - |
Wolbachia sp. subsp. Brugia malayi | |
1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one | - |
Wolbachia sp. subsp. Brugia malayi | |
2,7-bis[(3,4,5-trimethoxyphenyl)methyl]cycloheptan-1-one | - |
Wolbachia sp. subsp. Brugia malayi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Wolbachia sp. subsp. Brugia malayi | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Wolbachia sp. subsp. Brugia malayi TRS | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Wolbachia sp. subsp. Brugia malayi | Q5GS88 | - |
- |
Wolbachia sp. subsp. Brugia malayi TRS | Q5GS88 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography | Wolbachia sp. subsp. Brugia malayi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Wolbachia sp. subsp. Brugia malayi | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Wolbachia sp. subsp. Brugia malayi TRS | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LigA | - |
Wolbachia sp. subsp. Brugia malayi |
NAD+-dependent DNA ligase | - |
Wolbachia sp. subsp. Brugia malayi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Wolbachia sp. subsp. Brugia malayi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00102 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 2,7-bis[(3,4,5-trimethoxyphenyl)methyl]cycloheptan-1-one | |
0.0023 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 1,6-bis(4-fluorophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | |
0.0029 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 1,6-bis(4-bromophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | |
0.0058 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | |
0.015 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one | |
0.0177 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one | |
0.354 | - |
at pH 8.0 and 20°C | Wolbachia sp. subsp. Brugia malayi | 1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one |