Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21-DE3-RIL cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
X1BRCTb complexed with L3BRCT | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49916 | - |
- |
Purification (Comment) | Organism |
---|---|
immobilized metal affinity column chromatography and Superdex S75 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Homo sapiens | AMP + diphosphate + (deoxyribonucleotide)m+n | - |
? | |
additional information | for efficient ligation, ligase III-alpha is constitutively bound to the scaffolding protein XRCC1 through interactions between the C-terminal BRCT domains of each protein | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | x-ray crystallography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DNA ligase III | - |
Homo sapiens |
L3BRCT | C-terminal ligase III-alpha BRCT domain | Homo sapiens |
ligase III-alpha | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |