Literature summary for 6.3.4.5 extracted from

Bateman, L.A.; Ku, W.M.; Heslin, M.J.; Contreras, C.M.; Skibola, C.F.; Nomura, D.K.
Argininosuccinate synthase 1 is a metabolic regulator of colorectal cancer pathogenicity (2017), ACS Chem. Biol., 12, 905-911 .

Search for more literature for 6.3.4.5

Application

Application	Comment	Organism
medicine	argininosuccinate synthase 1 is upregulated in primary human colorectal tumors and pharmacological inhibition or genetic ablation of ASS1 impairs colorectal cancer pathogenicity. ASS1 inhibition leads to reductions in the levels of oncogenic metabolite fumarate, leading to impairments in glycolytic metabolism that supports colorectal cancer cell pathogenicity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00966	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-
SW-620 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ASS1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	gene expression is upregulated in primary human colorectal tumors	up

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Release 2023.1 (January 2023)