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Literature summary for 6.3.4.5 extracted from

  • Bowles, T.L.; Kim, R.; Galante, J.; Parsons, C.M.; Virudachalam, S.; Kung, H.J.; Bold, R.J.
    Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase (2008), Int. J. Cancer, 123, 1950-1955.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.5

Inhibitors

Inhibitors Comment Organism Structure
additional information pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-citrulline + L-aspartate Homo sapiens
-
 AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
additional information Homo sapiens pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BxPC-3 cell pancreatic cancer cell line, low ASS expression level Homo sapiens
-
CAPAN-1 cell pancreatic cancer cell line, low ASS expression level Homo sapiens
-
HPAC cell pancreatic cancer cell line, low ASS expression level Homo sapiens
-
HPAF-2 cell pancreatic cancer cell line, low ASS expression level Homo sapiens
-
MiaPaCa-2 cell pancreatic cancer cell line, very low ASS expression level Homo sapiens
-
additional information 87% of human tumors and 5 of 7 cancer cell lines lack ASS expression, overview Homo sapiens
-
PANC-1 cell pancreatic cancer cell line, very low ASS expression level Homo sapiens
-
pancreatic cancer cell line pancreatic cancer cell line, low ASS expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-citrulline + L-aspartate
-
 Homo sapiens AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
additional information pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Argininosuccinate synthetase
-
 Homo sapiens
ASS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens