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Literature summary for 6.3.4.5 extracted from

  • Kumar, S.; Lennane, J.; Ratner, S.
    Argininosuccinate synthetase: essential role of cysteine and arginine residues in relation to structure and mechanism of ATP activation (1985), Proc. Natl. Acad. Sci. USA, 82, 6745-6749.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.5

Inhibitors

Inhibitors Comment Organism Structure
Phenylglyoxal ATP and diphosphate protect Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate essential Arg in the active site participates in the binding of ATP and diphosphate. The binding of ATP and diphosphate at the same site is mutually exclusive Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-citrulline + L-Asp
-
 Bos taurus AMP + diphosphate + L-argininosuccinate
-
 ?