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Literature summary for 6.3.2.62 extracted from

  • Garnham, C.P.; Yu, I.; Li, Y.; Roll-Mecak, A.
    Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases (2017), Proc. Natl. Acad. Sci. USA, 114, 6545-6550 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.62

Localization

Localization Comment Organism GeneOntology No. Textmining
axoneme
-
 Homo sapiens 5930
-
cilium
-
 Homo sapiens 5929
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate Homo sapiens overall reaction [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6ZT98
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate overall reaction Homo sapiens [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate overall reaction. There are two main glutamylation sites in beta-tubulin: E434 and E441. E442 and E443 are also modified, but with much lower frequency Homo sapiens [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

Synonyms Comment Organism
beta-tubulin-specific glutamylase
-
 Homo sapiens
TTLL7 isoform Homo sapiens
tubulin tyrosine ligase-like 7
-
 Homo sapiens