Literature summary for 6.3.2.4 extracted from

Feng, Z.; Barletta, R.G.
Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine (2003), Antimicrob. Agents Chemother., 47, 283-291.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of Ddl in Mycobacterium smegmatis	Mycobacterium tuberculosis
overexpression of Ddl in Mycobacterium smegmatis	Mycolicibacterium smegmatis

Inhibitors

Inhibitors	Comment	Organism	Structure
D-cycloserine	0.2 mg/ml, approx. 60% inhibition, 0.8 mg/ml, approx. 95% inhibition	Mycobacterium tuberculosis
D-cycloserine	0.2 mg/ml, approx. 50% inhibition, 0.8 mg/ml, approx. 80% inhibition	Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + D-alanine	Mycobacterium tuberculosis	-	ADP + phosphate + D-alanyl-D-alanine	-	?
ATP + D-alanine	Mycolicibacterium smegmatis	-	ADP + phosphate + D-alanyl-D-alanine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
Mycolicibacterium smegmatis	Q9ZGN0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-alanine	-	Mycobacterium tuberculosis	ADP + phosphate + D-alanyl-D-alanine	-	?
ATP + D-alanine	-	Mycolicibacterium smegmatis	ADP + phosphate + D-alanyl-D-alanine	-	?

Synonyms

Synonyms	Comment	Organism
Ddl	-	Mycobacterium tuberculosis
Ddl	-	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)