BRENDA - Enzyme Database show
show all sequences of 6.3.2.1

Pantothenate synthetase from Escherichia coli [D-pantoate:beta-alanine ligase (AMP-forming), EC 6.3.2.1]

Miyatake, K.; Nakano, Y.; Kitaoka, S.; Methods Enzymol. 62, 215-219 (1979)

Data extracted from this reference:

General Stability
General Stability
Organism
lyophilized enzyme is very stable
Escherichia coli
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
-
Escherichia coli
4-Amino-3-hydroxybutanoate
32% inhibition at 1 mM
Escherichia coli
4-aminobutanoate
27% inhibition at 1 mM
Escherichia coli
Ag+
-
Escherichia coli
aspartate
24% inhibition at 1 mM
Escherichia coli
Ba2+
-
Escherichia coli
Ca2+
-
Escherichia coli
Co2+
-
Escherichia coli
Cu2+
-
Escherichia coli
EDTA
-
Escherichia coli
EGTA
-
Escherichia coli
Fe2+
slight
Escherichia coli
gluconate
32% inhibition at 1 mM
Escherichia coli
glycolate
30% inhibition at 1 mM
Escherichia coli
Hg2+
-
Escherichia coli
methylmalonate
38% inhibition at 1 mM
Escherichia coli
Mg2+
inhibition above 10 mM
Escherichia coli
Mn2+
inhibition above 5 mM
Escherichia coli
Ni2+
slight
Escherichia coli
Pb2+
slight
Escherichia coli
Sn2+
slight
Escherichia coli
Sr2+
slight
Escherichia coli
taurine
52% inhibition at 1 mM
Escherichia coli
Zn2+
-
Escherichia coli
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.063
-
D-pantoate
-
Escherichia coli
0.1
-
ATP
-
Escherichia coli
0.15
-
beta-Alanine
-
Escherichia coli
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
K+
activates; Km: 5.5 mM
Escherichia coli
Mg2+
divalent cation required, Mg2+ or Mn2+, Km: 2.0 mM. Optimal concentration: 10 mM, inhibition above
Escherichia coli
Mn2+
divalent cation required, Mg2+ or Mn2+. Optimal concentration: 5 mM, inhibition above
Escherichia coli
NH4+
activates
Escherichia coli
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
18000
-
x * 18000, SDS-PAGE in presence of 2-mercaptoethanol
Escherichia coli
69000
-
gel filtration
Escherichia coli
70000
-
sedimentation equilibrium ultracentrifugation
Escherichia coli
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
IFO 13168
-
Purification (Commentary)
Commentary
Organism
-
Escherichia coli
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
2.05
-
-
Escherichia coli
Storage Stability
Storage Stability
Organism
-20C, stable for 6 months
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (R)-pantoate + beta-alanine
-
977
Escherichia coli
AMP + diphosphate + (R)-pantothenate
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 18000, SDS-PAGE in presence of 2-mercaptoethanol
Escherichia coli
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
37
-
pH 5.0-10.0, 15 min stable
Escherichia coli
General Stability (protein specific)
General Stability
Organism
lyophilized enzyme is very stable
Escherichia coli
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
-
Escherichia coli
4-Amino-3-hydroxybutanoate
32% inhibition at 1 mM
Escherichia coli
4-aminobutanoate
27% inhibition at 1 mM
Escherichia coli
Ag+
-
Escherichia coli
aspartate
24% inhibition at 1 mM
Escherichia coli
Ba2+
-
Escherichia coli
Ca2+
-
Escherichia coli
Co2+
-
Escherichia coli
Cu2+
-
Escherichia coli
EDTA
-
Escherichia coli
EGTA
-
Escherichia coli
Fe2+
slight
Escherichia coli
gluconate
32% inhibition at 1 mM
Escherichia coli
glycolate
30% inhibition at 1 mM
Escherichia coli
Hg2+
-
Escherichia coli
methylmalonate
38% inhibition at 1 mM
Escherichia coli
Mg2+
inhibition above 10 mM
Escherichia coli
Mn2+
inhibition above 5 mM
Escherichia coli
Ni2+
slight
Escherichia coli
Pb2+
slight
Escherichia coli
Sn2+
slight
Escherichia coli
Sr2+
slight
Escherichia coli
taurine
52% inhibition at 1 mM
Escherichia coli
Zn2+
-
Escherichia coli
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.063
-
D-pantoate
-
Escherichia coli
0.1
-
ATP
-
Escherichia coli
0.15
-
beta-Alanine
-
Escherichia coli
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
K+
activates; Km: 5.5 mM
Escherichia coli
Mg2+
divalent cation required, Mg2+ or Mn2+, Km: 2.0 mM. Optimal concentration: 10 mM, inhibition above
Escherichia coli
Mn2+
divalent cation required, Mg2+ or Mn2+. Optimal concentration: 5 mM, inhibition above
Escherichia coli
NH4+
activates
Escherichia coli
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
18000
-
x * 18000, SDS-PAGE in presence of 2-mercaptoethanol
Escherichia coli
69000
-
gel filtration
Escherichia coli
70000
-
sedimentation equilibrium ultracentrifugation
Escherichia coli
Purification (Commentary) (protein specific)
Commentary
Organism
-
Escherichia coli
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
2.05
-
-
Escherichia coli
Storage Stability (protein specific)
Storage Stability
Organism
-20C, stable for 6 months
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (R)-pantoate + beta-alanine
-
977
Escherichia coli
AMP + diphosphate + (R)-pantothenate
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 18000, SDS-PAGE in presence of 2-mercaptoethanol
Escherichia coli
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
37
-
pH 5.0-10.0, 15 min stable
Escherichia coli
Other publictions for EC 6.3.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746489
Pandey
Alanine mutation of the catal ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv
Sci. Rep.
8
903
2018
-
-
-
-
7
-
-
-
-
1
-
2
-
6
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
7
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744489
Samala
Design, synthesis and biologi ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
Bioorg. Med. Chem.
24
1298-1307
2016
-
-
1
-
-
-
35
-
-
1
-
2
-
7
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
32
-
-
1
1
-
-
-
32
35
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
744723
Hung
Optimization of inhibitors of ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv
ChemMedChem
11
38-42
2016
-
-
-
-
-
-
16
-
-
1
-
2
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
16
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745786
Devi
Design of novel Mycobacterium ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv
Mol. Inform.
34
147-159
2015
-
-
1
1
-
-
31
-
-
1
-
2
-
6
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
16
-
-
1
1
1
-
-
16
31
-
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
727169
Samala
Development of novel tetrahydr ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bioorg. Med. Chem.
22
1938-1947
2014
-
-
1
-
-
-
27
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
26
-
-
1
-
-
-
-
26
27
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744484
Samala
Identification and developmen ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
Bioorg. Med. Chem.
22
4223-4232
2014
-
-
-
-
-
-
37
-
-
1
-
2
-
5
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
32
-
-
-
1
-
-
-
32
37
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
744725
Devi
Structure-guided design of th ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
ChemMedChem
9
2538-2547
2014
-
1
-
-
-
-
27
-
-
1
-
2
-
5
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
7
-
1
-
1
-
-
-
7
27
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
745742
Ntie-Kang
Binding of pyrazole-based inh ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 / H37Rv
Mol. Biosyst.
10
223-239
2014
-
1
-
-
-
-
1
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727423
Samala
Development of 3-phenyl-4,5,6, ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Eur. J. Med. Chem.
69
356-364
2013
-
-
-
-
-
-
46
-
-
-
-
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
6
-
-
-
-
-
-
-
6
46
3
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728622
Kumar
A high-throughput screen again ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
8
e72786
2013
-
-
1
-
-
-
4
-
-
1
-
2
-
11
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
2
-
-
-
-
1
1
-
-
-
-
4
2
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714435
Yang
A discovery of novel Mycobacte ...
Mycobacterium tuberculosis
Bioorg. Med. Chem. Lett.
21
3943-3946
2011
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716880
Tan
A comparison of the dynamics o ...
Escherichia coli, Mycobacterium tuberculosis
Proteins
79
1715-1727
2011
-
-
-
2
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703685
Chakrabarti
X-ray crystallographic and NMR ...
Escherichia coli
FEBS J.
277
697-712
2010
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704206
Sledz
Optimization of the interligan ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Am. Chem. Soc.
132
4544-4545
2010
-
-
-
1
-
-
3
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714204
Satoh
Substrate-induced closing of t ...
Staphylococcus aureus
Biochemistry
49
6400-6410
2010
-
-
1
1
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
1
-
-
2
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
2
1
1
-
-
-
-
-
-
-
-
693541
Velaparthi
5-tert-butyl-N-pyrazol-4-yl-4, ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Med. Chem.
51
1999-2002
2008
-
-
-
-
-
-
20
-
-
1
-
1
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
15
-
-
-
1
-
-
-
15
20
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694696
Jonczyk
Pantothenate synthetase is ess ...
Arabidopsis thaliana, Escherichia coli
Plant Mol. Biol.
66
1-14
2008
-
-
2
-
1
-
-
-
-
2
-
3
-
5
-
-
1
-
-
2
-
-
3
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
2
-
1
-
-
-
-
-
-
2
-
3
-
-
-
1
-
2
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
674945
White
A novel inhibitor of Mycobacte ...
Mycobacterium tuberculosis
J. Biomol. Screen.
12
100-105
2007
-
-
-
-
-
-
1
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672114
Wang
Crystal structure of the panto ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochemistry
45
1554-1561
2006
-
-
-
1
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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