Literature summary for 6.3.1.8 extracted from

Chiang, B.Y.; Chen, T.C.; Pai, C.H.; Chou, C.C.; Chen, H.H.; Ko, T.P.; Hsu, W.H.; Chang, C.Y.; Wu, W.F.; Wang, A.H.; Lin, C.H.
Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetase/amidase in redox regulation (2010), J. Biol. Chem., 285, 25345-25353.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	H2O2 leads to inhibition of the amidase activity, while the glutathionylspermidine synthase activity is almost unaffected	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AES0	bifunctional glutathionylspermidine synthetase/amidase	-

Synonyms

Synonyms	Comment	Organism
GspSA	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	hypersensitivities of the GspSA/glutaredoxin null mutants to H2O2 support the idea that GspSA and Grx synergistically defend against oxidative damage	Escherichia coli

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Release 2023.1 (January 2023)