Literature summary for 6.3.1.8 extracted from

Amssoms, K.; Oza, S.L.; Augustyns, K.; Yamani, A.; Lambeir, A.M.; Bal, G.; Van der Veken, P.; Fairlamb, A.H.; Haemers, A.
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: Substitution of the glycine part (2002), Bioorg. Med. Chem. Lett., 12, 2703-2705.

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Inhibitors

Inhibitors	Comment	Organism	Structure
gamma-L-glutamyl-L-cysteinyl-diaminopropionic acid	-	Crithidia fasciculata
additional information	a series of glutathione analogs where the glycine moiety is substituted for other amino acids can act as inhibitors	Crithidia fasciculata

Organism

Organism	UniProt	Comment	Textmining
Crithidia fasciculata	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
gamma-L-Glu-L-Cys-Gly + spermidine + MgATP2-	substitution of the glycine part abolishes activity	Crithidia fasciculata	N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + MgADP- + phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
7.2	-	gamma-L-glutamyl-L-cysteinyl-diaminopropionic acid	-	Crithidia fasciculata

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Release 2023.1 (January 2023)