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Literature summary for 6.3.1.19 extracted from

  • Smirnov, D.; Dhall, A.; Sivanesam, K.; Sharar, R.J.; Chatterjee, C.
    Fluorescent probes reveal a minimal ligase recognition motif in the prokaryotic ubiquitin-like protein from Mycobacterium tuberculosis (2013), J. Am. Chem. Soc., 135, 2887-2890.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WNU7
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Mycobacterium tuberculosis ATCC 25618 P9WNU7
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine the C-terminal 26 amino acid sequence of the prokaryotic ubiquitin-like protein (Pup) is the minimal ligase recognition motif in Mycobacterium tuberculosis. Specific hydrophobic residues within this sequence that are known to be important for the interactions of Pup with proteasomes are also critical for the activation of Pup by PafA Mycobacterium tuberculosis ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
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 ?
ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine the C-terminal 26 amino acid sequence of the prokaryotic ubiquitin-like protein (Pup) is the minimal ligase recognition motif in Mycobacterium tuberculosis. Specific hydrophobic residues within this sequence that are known to be important for the interactions of Pup with proteasomes are also critical for the activation of Pup by PafA Mycobacterium tuberculosis ATCC 25618 ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine
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 ?

Synonyms

Synonyms Comment Organism
PafA ambiguous Mycobacterium tuberculosis
Pup ligase
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 Mycobacterium tuberculosis