Literature summary for 6.2.1.58 extracted from

Junghare, M.; Spiteller, D.; Schink, B.
Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans (2019), ISME J., 13, 1252-1268 .

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Organism

Organism	UniProt	Comment	Textmining
Syntrophorhabdus aromaticivorans	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.073	-	cell-free extract, pH 7.6, temperature not specified in the publication	Syntrophorhabdus aromaticivorans

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + isophthalate + CoA	-	Syntrophorhabdus aromaticivorans	AMP + diphosphate + isophthalyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
IPCL	-	Syntrophorhabdus aromaticivorans

Expression

Organism	Comment	Expression
Syntrophorhabdus aromaticivorans	expression is specifically induced by growth on isophthalate	up

General Information

General Information	Comment	Organism
physiological function	in isophthalate-grown cells, isophthalate is activated to isophthalyl-CoA by ATP-dependent isophthalate:CoA ligase, and subsequently decarboxylated to benzoyl-CoA by UbiD family isophthalyl-CoA decarboxylase (IPCD, EC 4.1.1.118) that requires a prenylated flavin mononucleotide cofactor supplied by UbiX to effect decarboxylation	Syntrophorhabdus aromaticivorans

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Release 2023.1 (January 2023)