Cloned (Comment) | Organism |
---|---|
gene UBA1, real-time quantitative PCR enzyme expression analysis | Ovis aries |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine | Ovis aries | - |
AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | A0A6P7D3I5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | ovine thymuses are sampled on day 16 of the estrous cycle and on days 13, 16 and 25 of gestation, and UBE1L is detected by real-time quantitative PCR, Western blot and immunohistochemistry. The expression of UBE1L is declined during early pregnancy | Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine | - |
Ovis aries | AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UBA7 | - |
Ovis aries |
UBE1L | - |
Ovis aries |
ubiquitin activating enzyme E1-like | - |
Ovis aries |
ubiquitin-like modifier-activating enzyme 7 isoform X2 | UniProt | Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Ovis aries |
Organism | Comment | Expression |
---|---|---|
Ovis aries | expression of UBE1L declines during early pregnancy | down |
General Information | Comment | Organism |
---|---|---|
metabolism | early pregnancy influences expression of STAT1, Mx1, IP-10 and UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep | Ovis aries |
physiological function | early pregnancy reduces expression of UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep | Ovis aries |