Cloned (Comment) | Organism |
---|---|
a plasmid with a His-tagged fusion protein is constructed for expression in Escherichia coli | Mycobacterium avium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxydodecanoic acid | - |
Mycobacterium avium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
dodecanoate | - |
Mycobacterium avium | |
0.036 | - |
ATP | - |
Mycobacterium avium | |
0.045 | - |
CoA | - |
Mycobacterium avium | |
0.285 | - |
Octanoate | - |
Mycobacterium avium | |
1.775 | - |
Decanoate | - |
Mycobacterium avium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mycobacterium avium | the enzyme is involved in the metabolism of fatty acid during mycobacterial survival in macrophages | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium avium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium avium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2-aminobenzoate + CoA | 1.4% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + 2-aminobenzoyl-CoA | - |
? | |
ATP + arachidonic acid + CoA | 5.2% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
ATP + benzoate + CoA | 2.3% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + benzoyl-CoA | - |
? | |
ATP + decanoate + CoA | substrate with the highest activity | Mycobacterium avium | AMP + diphosphate + decanoyl-CoA | - |
? | |
ATP + dodecanoate + CoA | 31% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + dodecanoyl-CoA | - |
? | |
ATP + heptanoate + CoA | 34% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + heptanoyl-CoA | - |
? | |
ATP + hexanoate + CoA | 35% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + hexanoyl-CoA | - |
? | |
ATP + linolenic acid + CoA | 8.3% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + linolenoyl-CoA | - |
? | |
ATP + m-hydroxybenzoate + CoA | 0.8% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + m-hydroxybenzoyl-CoA | - |
? | |
ATP + octanoate + CoA | 31% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + octanoyl-CoA | - |
? | |
ATP + pentanoate + CoA | 1.6% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + pentanoyl-CoA | - |
? | |
ATP + tetradecanoate + CoA | 3.9% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + tetradecanoyl-CoA | - |
? | |
ATP + tridecanoate + CoA | 15% of the activity with dodecanoate | Mycobacterium avium | AMP + diphosphate + tridecanoyl-CoA | - |
? | |
additional information | the enzyme is involved in the metabolism of fatty acid during mycobacterial survival in macrophages | Mycobacterium avium | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Mig protein | - |
Mycobacterium avium |