Literature summary for 5.6.2.1 extracted from

Tiwari, P.B.; Chapagain, P.P.; Banda, S.; Darici, Y.; Ueren, A.; Tse-Dinh, Y.C.
Characterization of molecular interactions between Escherichia coli RNA polymerase and topoisomerase I by molecular simulations (2016), FEBS Lett., 590, 2844-2851 .

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	contains Zn2+	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
supercoiled DNA	Escherichia coli	the enzyme relaxes the negative DNA supercoiling generated by RNA polymerase during transcription elongation	relaxed DNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P06612	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA	the enzyme relaxes the negative DNA supercoiling generated by RNA polymerase during transcription elongation	Escherichia coli	relaxed DNA	-	?

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase I	-	Escherichia coli
topoI	-	Escherichia coli

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Release 2023.1 (January 2023)