Literature summary for 5.6.2.1 extracted from

Puc, J.; Kozbial, P.; Li, W.; Tan, Y.; Liu, Z.; Suter, T.; Ohgi, K.A.; Zhang, J.; Aggarwal, A.K.; Rosenfeld, M.G.
Ligand-dependent enhancer activation regulated by topoisomerase-I activity (2015), Cell, 160, 367-380 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	-	Homo sapiens	-
prostate cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Top1	-	Homo sapiens
topoisomerase-I	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	DANN topoisomerase I is a critical DNA-nicking enzyme involved in the process of cell-specific, ligand-driven enhancer activation. The enzyme occupies androgen receptor-enhancers KLK3 and KLK2 and affects the transcriptional program of the prostate cancer cell line LNCaP	Homo sapiens

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Release 2023.1 (January 2023)