Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[3-[ethyl(methyl)amino]propyl]furo[3,2-c]phenanthridine-5,10,11(4H)-trione | - |
Homo sapiens | |
hydroxylcamptothecin | topoisomerase I inhibitor | Homo sapiens | |
N,N-dimethyl(6-methyl-10,11-dioxo-10,11-dihydrophenanthro[1,2-b]furan-1-yl)methanaminium (2E)-3-carboxyprop-2-enoate | - |
Homo sapiens | |
tanshinone-1 | less than 10% inhibition at 0.005 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11387 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
BEL-7402 cell | - |
Homo sapiens | - |
CAL-51 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HCT-15 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
KB cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-436 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
MX-1 cell | - |
Homo sapiens | - |
SMMC-7721 cell | - |
Homo sapiens | - |
SPC-A4 cell | - |
Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
UWB1.289 cell | - |
Homo sapiens | - |
UWB1.289+BRCA1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
supercoiled plasmid DNA pBR322 | - |
Homo sapiens | relaxed plasmid DNA pBR322 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA topoisomerase I | - |
Homo sapiens |
Top1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.02149 | - |
at pH 8.0 and 37°C | Homo sapiens | tanshinone-1 |