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Literature summary for 5.6.2.1 extracted from

  • Terekhova, K.; Marko, J.F.; Mondragon, A.
    Studies of bacterial topoisomerases I and III at the single-molecule level (2013), Biochem. Soc. Trans., 41, 571-575.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Reaction

Reaction Comment Organism Reaction ID
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining mechanism of DNA relaxation for type IA topoisomerases, overview Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information single-molecule DNA relaxation assay, the pauses of the enzyme are short and the relaxation runs are slow Escherichia coli ?
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 ?

Synonyms

Synonyms Comment Organism
Topoisomerase I
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 Escherichia coli
type IA topoisomerase
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 Escherichia coli

General Information

General Information Comment Organism
evolution type IA enzymes are ubiquitous. They are present in bacteria, archaea and eukarya. Although all type IA topoisomerases are related at the sequence, structure and mechanism levels, different type IA enzymes do not participate in the same cellular processes. For topoisomerase I in DNA relaxation reaction, the pauses are short and the relaxation runs are slow, while topoisomerase III behaves the opposite way: the the pauses are long and the relaxation runs are fast. The combination of these two general features results in topoisomerase I having a higher overall relaxation rate than topoisomerase III Escherichia coli
physiological function topoisomerases are the enzymes responsible for maintaining the supercoiled state of DNA in the cell and also for many other DNA-topology-associated reactions. Type IA enzymes alter DNA topology by breaking one DNA strand and passing another strand or strands through the break Escherichia coli