Literature summary for 5.6.2.1 extracted from

Oksuzoglu, E.; Tekiner-Gulbas, B.; Alper, S.; Temiz-Arpaci, O.; Ertan, T.; Yildiz, I.; Diril, N.; Sener-Aki, E.; Yalcin, I.
Some benzoxazoles and benzimidazoles as DNA topoisomerase I and II inhibitors (2008), J. Enzyme Inhib. Med. Chem., 23, 37-42.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(4-chlorobenzyl)benzoxazole	-	Bos taurus
2-phenoxymethylbenzimidazole	-	Bos taurus
5-amino-2-(4-amino-2-bromophenyl)benzoxazole	-	Bos taurus
5-amino-2-(4-fluorophenyl)benzoxazole	-	Bos taurus
5-amino-2-phenylbenzoxazole	-	Bos taurus
5-nitro-2-phenoxymethyl-benzimidazole	-	Bos taurus
camptothecin	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P68698	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase I	-	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0141	-	-	Bos taurus	2-phenoxymethylbenzimidazole
0.1323	-	-	Bos taurus	5-amino-2-(4-fluorophenyl)benzoxazole
0.1341	-	-	Bos taurus	5-amino-2-(4-amino-2-bromophenyl)benzoxazole
0.248	-	-	Bos taurus	5-nitro-2-phenoxymethyl-benzimidazole
0.4435	-	-	Bos taurus	2-(4-chlorobenzyl)benzoxazole
0.495	-	-	Bos taurus	5-amino-2-phenylbenzoxazole
0.526	-	-	Bos taurus	camptothecin

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Release 2023.1 (January 2023)