Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[4-[(4,11-dihydroxy-5,10-dioxo-5,10-dihydro-1H-naphtho[2,3-f]indol-3-yl)methyl]piperazin-1-yl]ethyl acetate | - |
Homo sapiens | |
3-[(1-azabicyclo[2.2.2]oct-3-ylamino)methyl]-4,11-dihydroxy-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
3-[(dimethylamino)methyl]-4,11-dihydroxy-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
4,11-bis([2-[(2-hydroxyethyl)amino]ethyl]amino)-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
4,11-bis[(2-aminoethyl)amino]-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
4,11-bis[[2-(dimethylamino)ethyl]amino]-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
4,11-bis{[2-(methylamino)ethyl]amino}-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
4,11-dihydroxy-3-[(4-methylpiperazin-1-yl)methyl]-1H-naphtho[2,3-f]indole-5,10-dione | - |
Homo sapiens | |
camptothecine | - |
Homo sapiens | |
doxorubicin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Topo I | - |
Homo sapiens |
Topoisomerase I | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0015 | - |
IC50 values 0.0005 mM to 0.0015 mM for 4,11-bis([2-[(2-hydroxyethyl)amino]ethyl]amino)-1H-naphtho[2,3-f]indole-5,10-dione, 0.0015 mM to 0.0035 mM for 4,11-bis[[2-(methylamino)ethyl]amino]-1H-naphtho[2,3-f]indole-5,10-dione, above 0.0035 mM for 4,11-bis[[2-(dimethylamino)ethyl]amino]-1H-naphtho[2,3-f]indole-5,10-dione | Homo sapiens | 4,11-bis[(2-aminoethyl)amino]-1H-naphtho[2,3-f]indole-5,10-dione |