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Literature summary for 5.6.2.1 extracted from

  • Cheng, Y.; An, L.K.; Wu, N.; Wang, X.D.; Bu, X.Z.; Huang, Z.S.; Gu, L.Q.
    Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives (2008), Bioorg. Med. Chem., 16, 4617-4625.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
11-acetyl-10-amino-indolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
11-acetyl-10-bromo-indolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
11-acetyl-10-chloro-indolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
11-acetyl-10-fluoro-indolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
11-acetyl-10-hydroxy-indolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
11-acetylindolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
11-methylindolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens
5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carbonitrile
-
 Homo sapiens
5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline-11-carbonitrile
-
 Homo sapiens
6-acetyl-7-amino-indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-acetyl-7-bromo-indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-acetyl-7-chloro-indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-acetyl-7-fluoro-indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-acetyl-7-hydroxy-indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-acetylindolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-methylindolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
camptothecin
-
 Homo sapiens
ethyl 10-amino-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 10-bromo-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 10-chloro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 10-fluoro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 10-hydroxy-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 10-methyl-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]isoquinoline-6-carboxylate
-
 Homo sapiens
ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]isoquinoline-11-carboxylate
-
 Homo sapiens
ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
-
 Homo sapiens
ethyl 6,11-dioxo-6,11-dihydrobenzo[f]-pyrido[1,2-alpha]indole 12-carboxylate
-
 Homo sapiens
ethyl 7-amino-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
ethyl 7-bromo-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
ethyl 7-chloro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
ethyl 7-fluoro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
ethyl 7-hydroxy-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
ethyl 7-methyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
-
 Homo sapiens
indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
indolizino[3,2-g]quinoline-5,12-dione
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
GLC-82 cell human lung adenocarcinoma cell line Homo sapiens
-
HL-60 cell promyelocytic leukemia cell line Homo sapiens
-
MCF-7 cell breast carcinoma cell line Homo sapiens
-
NCI-H460 cell large-cell lung carcinoma cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA topoisomerase I
-
 Homo sapiens
Top1
-
 Homo sapiens
Topoisomerase I
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 for a mixture of ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]isoquinoline-6-carboxylate and ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]isoquinoline-11-carboxylate the IC50 values are 0.00936 mM for GLC-82 cells, 0.01170 mM for MCF-7 cells, 0.0022 mM for NCI-H460 cells, and 0.01743 mM for HL-60 cells. For a mixture of 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carbonitrile and 5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline-11-carbonitrile the IC50 values are 0.01267 mM for HL-60 cells, 0.00250 mM for GLC-82 cells, 0.00156 mM for MCF-7 cells, and 0.00016 mM for NCI-H460 cells Homo sapiens additional information
0.00017
-
 for HL-60 cells Homo sapiens 6-acetyl-7-fluoro-indolizino[2,3-g]quinoline-5,12-dione
0.00019
-
 for HL-60 cells Homo sapiens 6-acetyl-7-chloro-indolizino[2,3-g]quinoline-5,12-dione
0.0002
-
 for NCI-H460 cells Homo sapiens 11-acetyl-10-bromo-indolizino[3,2-g]quinoline-5,12-dione
0.00021
-
 for HL-60 cells Homo sapiens 6-acetyl-7-bromo-indolizino[2,3-g]quinoline-5,12-dione
0.00022
-
 for HL-60 cells Homo sapiens ethyl 7-methyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00023
-
 for NCI-H460 cells Homo sapiens 6-acetyl-7-chloro-indolizino[2,3-g]quinoline-5,12-dione
0.00086
-
 for HL-60 cells Homo sapiens 6-acetylindolizino[2,3-g]quinoline-5,12-dione
0.00088
-
 for HL-60 cells Homo sapiens ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00096
-
 for MCF-7 cells Homo sapiens ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0011
-
 for GLC-82 cells Homo sapiens ethyl 10-bromo-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0012
-
 for NCI-H460 cells Homo sapiens ethyl 10-fluoro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00137
-
 for HL-60 cells Homo sapiens ethyl 7-fluoro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00139
-
 for HL-60 cells Homo sapiens 11-acetyl-10-fluoro-indolizino[3,2-g]quinoline-5,12-dione
0.0014
-
 for NCI-H460 cells Homo sapiens 11-acetylindolizino[3,2-g]quinoline-5,12-dione
0.0015
-
 for NCI-H460 cells Homo sapiens 11-acetyl-10-chloro-indolizino[3,2-g]quinoline-5,12-dione
0.00156
-
 for HL-60 cells Homo sapiens 11-acetyl-10-bromo-indolizino[3,2-g]quinoline-5,12-dione
0.0017
-
 for GLC-82 cells Homo sapiens ethyl 10-fluoro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00183
-
 for GLC-82 cells Homo sapiens ethyl 7-methyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0019
-
 for GLC-82 cells Homo sapiens 11-acetylindolizino[3,2-g]quinoline-5,12-dione
0.0019
-
 for NCI-H460 cells Homo sapiens ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.002
-
 for NCI-H460 cells Homo sapiens ethyl 7-bromo-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00201
-
 for GLC-82 cells Homo sapiens 6-acetyl-7-bromo-indolizino[2,3-g]quinoline-5,12-dione
0.0021
-
 for NCI-H460 cells Homo sapiens ethyl 7-chloro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00215
-
 for NCI-H460 cells Homo sapiens 6-acetyl-7-bromo-indolizino[2,3-g]quinoline-5,12-dione
0.0022
-
 for NCI-H460 cells Homo sapiens ethyl 10-chloro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00231
-
 for MCF-7 cells Homo sapiens 6-acetyl-7-fluoro-indolizino[2,3-g]quinoline-5,12-dione
0.0024
-
 for GLC-82 cells Homo sapiens ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0024
-
 for NCI-H460 cells Homo sapiens ethyl 10-bromo-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00468
-
 for GLC-82 cells Homo sapiens 11-acetyl-10-bromo-indolizino[3,2-g]quinoline-5,12-dione
0.00526
-
 for GLC-82 cells Homo sapiens 6-acetyl-7-fluoro-indolizino[2,3-g]quinoline-5,12-dione
0.00551
-
 for HL-60 cells Homo sapiens ethyl 10-fluoro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0062
-
 for MCF-7 cells Homo sapiens ethyl 10-fluoro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00638
-
 for MCF-7 cells Homo sapiens ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00652
-
 for HL-60 cells Homo sapiens ethyl 7-chloro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00675
-
 for NCI-H460 cells Homo sapiens 11-acetyl-10-fluoro-indolizino[3,2-g]quinoline-5,12-dione
0.00685
-
 for GLC-82 cells Homo sapiens 6-acetyl-7-chloro-indolizino[2,3-g]quinoline-5,12-dione
0.00701
-
 for MCF-7 cells Homo sapiens ethyl 7-fluoro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0072
-
 for GLC-82 cells Homo sapiens ethyl 7-hydroxy-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00737
-
 for MCF-7 cells Homo sapiens ethyl 7-chloro-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00783
-
 for MCF-7 cells Homo sapiens 6-acetyl-7-chloro-indolizino[2,3-g]quinoline-5,12-dione
0.00792
-
 for MCF-7 cells Homo sapiens 6-acetylindolizino[2,3-g]quinoline-5,12-dione
0.00927
-
 for GLC-82 cells Homo sapiens ethyl 10-methyl-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.00928
-
 for MCF-7 cells Homo sapiens 11-acetyl-10-fluoro-indolizino[3,2-g]quinoline-5,12-dione
0.00932
-
 for HL-60 cells Homo sapiens ethyl 7-bromo-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.00973
-
 for GLC-82 cells Homo sapiens ethyl 10-chloro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.01029
-
 for NCI-H460 cells Homo sapiens 11-acetyl-10-amino-indolizino[3,2-g]quinoline-5,12-dione
0.0103
-
 for GLC-82 cells Homo sapiens 11-acetyl-10-amino-indolizino[3,2-g]quinoline-5,12-dione
0.0103
-
 for MCF-7 cells Homo sapiens ethyl 7-bromo-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.01147
-
 for HL-60 cells Homo sapiens ethyl 10-bromo-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0115
-
 for GLC-82 cells Homo sapiens indolizino[2,3-g]quinoline-5,12-dione
0.01165
-
 for HL-60 cells Homo sapiens ethyl 10-methyl-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0117
-
 for MCF-7 cells Homo sapiens 6-acetyl-7-bromo-indolizino[2,3-g]quinoline-5,12-dione
0.0122
-
 for GLC-82 cells Homo sapiens 6-acetyl-7-amino-indolizino[2,3-g]quinoline-5,12-dione
0.0122
-
 for NCI-H460 cells Homo sapiens 6-methylindolizino[2,3-g]quinoline-5,12-dione
0.0123
-
 for NCI-H460 cells Homo sapiens indolizino[3,2-g]quinoline-5,12-dione
0.0124
-
 for MCF-7 cells Homo sapiens 11-acetyl-10-bromo-indolizino[3,2-g]quinoline-5,12-dione
0.01246
-
 for HL-60 cells Homo sapiens 6-methylindolizino[2,3-g]quinoline-5,12-dione
0.0127
-
 for GLC-82 cells Homo sapiens 11-acetyl-10-fluoro-indolizino[3,2-g]quinoline-5,12-dione
0.0127
-
 for MCF-7 cells Homo sapiens 11-acetylindolizino[3,2-g]quinoline-5,12-dione
0.0142
-
 for GLC-82 cells Homo sapiens 6-methylindolizino[2,3-g]quinoline-5,12-dione
0.01445
-
 for HL-60 cells Homo sapiens ethyl 5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0145
-
 for MCF-7 cells Homo sapiens ethyl 7-methyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.01468
-
 for HL-60 cells Homo sapiens indolizino[3,2-g]quinoline-5,12-dione
0.01471
-
 for HL-60 cells Homo sapiens 11-acetylindolizino[3,2-g]quinoline-5,12-dione
0.01542
-
 for HL-60 cells Homo sapiens ethyl 10-chloro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0156
-
 for NCI-H460 cells Homo sapiens indolizino[2,3-g]quinoline-5,12-dione
0.0158
-
 for HL-60 cells Homo sapiens 11-acetyl-10-amino-indolizino[3,2-g]quinoline-5,12-dione
0.0161
-
 for GLC-82 cells Homo sapiens 11-acetyl-10-chloro-indolizino[3,2-g]quinoline-5,12-dione
0.0161
-
 for MCF-7 cells Homo sapiens 11-acetyl-10-chloro-indolizino[3,2-g]quinoline-5,12-dione
0.0163
-
 for GLC-82 cells Homo sapiens 11-acetyl-10-hydroxy-indolizino[3,2-g]quinoline-5,12-dione
0.01643
-
 for HL-60 cells Homo sapiens ethyl 7-amino-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0167
-
 for GLC-82 cells Homo sapiens indolizino[3,2-g]quinoline-5,12-dione
0.01697
-
 for HL-60 cells Homo sapiens indolizino[2,3-g]quinoline-5,12-dione
0.01758
-
 for NCI-H460 cells Homo sapiens ethyl 7-amino-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0176
-
 for MCF-7 cells Homo sapiens 6-acetyl-7-hydroxy-indolizino[2,3-g]quinoline-5,12-dione
0.019
-
 for NCI-H460 cells Homo sapiens ethyl 10-amino-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0195
-
 for GLC-82 cells Homo sapiens 6-acetyl-7-hydroxy-indolizino[2,3-g]quinoline-5,12-dione
0.0199
-
 for MCF-7 cells Homo sapiens ethyl 10-chloro-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0202
-
 for MCF-7 cells Homo sapiens indolizino[3,2-g]quinoline-5,12-dione
0.0208
-
 for MCF-7 cells Homo sapiens ethyl 10-bromo-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0209
-
 for MCF-7 cells Homo sapiens ethyl 7-amino-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0215
-
 for GLC-82 cells Homo sapiens 11-methylindolizino[3,2-g]quinoline-5,12-dione
0.022
-
 for HL-60 cells Homo sapiens 11-acetyl-10-chloro-indolizino[3,2-g]quinoline-5,12-dione
0.0223
-
 for HL-60 cells Homo sapiens 6-acetyl-7-amino-indolizino[2,3-g]quinoline-5,12-dione
0.0233
-
 for NCI-H460 cells Homo sapiens ethyl 10-hydroxy-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.02341
-
 for GLC-82 cells Homo sapiens ethyl 7-amino-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline 6-carboxylate
0.0235
-
 for GLC-82 cells Homo sapiens ethyl 10-amino-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.0238
-
 for GLC-82 cells Homo sapiens ethyl 10-hydroxy-5,12-dioxo-5,12-dihydroindolizino[3,2-g]quinoline 11-carboxylate
0.02485
-
 for NCI-H460 cells Homo sapiens 6-acetyl-7-hydroxy-indolizino[2,3-g]quinoline-5,12-dione