Literature summary for 5.6.1.3 extracted from

Uchimura, S.; Oguchi, Y.; Hachikubo, Y.; Ishiwata, S.; Muto, E.
Key residues on microtubule responsible for activation of kinesin ATPase (2010), EMBO J., 29, 1167-1175.

Search for more literature for 5.6.1.3

Cloned(Commentary)

Cloned (Comment)	Organism
truncated version HK560 (residue 1-560)	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + a kinesin associated with a microtubule at position n	Homo sapiens	-	ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + a kinesin associated with a microtubule at position n	-	Homo sapiens	ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)	-	?

Synonyms

Synonyms	Comment	Organism
HK560	truncated kinesin-1 (residue 1-560)	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
4.5	-	ATP	in presence of mutant microtubles alpha-E415A, pH 6.8, 25°C	Homo sapiens
17.6	-	ATP	in presence of mutant microtubles alpha-E416A, pH 6.8, 25°C	Homo sapiens
18	-	ATP	in presence of mutant microtubles alpha-E418A, pH 6.8, 25°C	Homo sapiens
20.7	-	ATP	in presence of mutant microtubles alpha-E421A, pH 6.8, 25°C	Homo sapiens
22	-	ATP	in presence of wild type microtubles, pH 6.8, 25°C	Homo sapiens
25.9	-	ATP	in presence of mutant microtubles beta-D417A, pH 6.8, 25°C	Homo sapiens
26.7	-	ATP	in presence of mutant microtubles beta-E410A, pH 6.8, 25°C	Homo sapiens

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Release 2023.1 (January 2023)