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Literature summary for 5.4.4.7 extracted from

  • Vierling, F.; Dick, A.; Wahlbuhl, M.; Krieg, P.; Henke, C.; Ruebner, M.; Schneider, H.
    Surprising prenatal toxicity of epidermal lipoxygenase-3 (2014), Placenta, 35, 776-779 .
    View publication on PubMed
Search for more literature for 5.4.4.7

Cloned(Commentary)

Cloned (Comment) Organism
gene Aloxe3, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, expression of the placenta-specific genes Tpbpa, Pcdh12, Muc1, Gcm1, SynA, and PL-1, encoding trophoblast-specific protein alpha, protocadherin 12, mucin 1, glial cell missing homologue 1, syncytin A, and placental lactogen 1, respectively, is analyzed in SYBR green-based real-time RT-PCR assays. Analysis of toxicity of eLOX-3 and dose-dependence of fetal survival, overview. Placentae from eLOX-3-exposed fetuses have an altered structure Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WV07
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Synonyms

Synonyms Comment Organism
ALOXE3
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 Mus musculus
eLOX-3
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 Mus musculus
epidermal lipoxygenase-3
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 Mus musculus

General Information

General Information Comment Organism
malfunction intra-amniotic delivery of epidermal lipoxygenase-3 (eLOX-3) to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, results in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicate a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression is altered. Thus, the observed prenatal toxicity of eLOX-3 can be due to a strong effect on placental development. Placentae from eLOX-3-exposed fetuses have an altered structure. Short life-span of eLOX-3 null mice Mus musculus
physiological function metabolites of the epidermal lipoxygenase-3 (eLOX-3) are involved in various metabolic pathways. Intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, results in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicate a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression is altered. Thus, the observed prenatal toxicity of eLOX-3 can be due to a strong effect on placental development. eLOX-3 appears to have some impact on the expression of genes that indirectly influence fetal development Mus musculus