Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required, chelated by residues D310, E313, and H348 | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Chorismate | Pseudomonas aeruginosa | - |
Isochorismate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Chorismate | - |
Pseudomonas aeruginosa | Isochorismate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
PchA | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme produces isochorismate for conversion to salicylate by isochorismate-pyruvate lyase, PchB, and incorporation into the pyochelin siderophore. Isochorismate synthase (PchA) and isochorismate-pyruvate lyase (PchB) from Pseudomonas aeurginosa are involved in the synthesis of the siderophore pyochelin | Pseudomonas aeruginosa |
additional information | structure-function relationships of chorismate-utilizing enzymes, structure comparisons, overview. Isochorismate synthase cannot perform any pericyclic reaction. Residues K221 and E269 are general base and acid, respectively | Pseudomonas aeruginosa |