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show all sequences of 5.4.3.6

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM

Montavon, T.J.; Christianson, C.V.; Festin, G.M.; Shen, B.; Bruner, S.D.; Bioorg. Med. Chem. Lett. 18, 3099-3102 (2008)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(2S,3R)-3-(4-fluorophenyl)oxirane-2-carboxylate
-
Streptomyces globisporus
(2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylate
-
Streptomyces globisporus
(2S,3R)-3-phenyloxirane-2-carboxylate
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-hydroxyphenyl)propanoate
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-methoxyphenyl)propanoate
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-phenylpropanoate
-
Streptomyces globisporus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Streptomyces globisporus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-tyrosine
-
691277
Streptomyces globisporus
3-amino-3-(4-hydroxyphenyl)propanoate
-
-
-
?
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3
-
-
Streptomyces globisporus
(2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylate
4.8
-
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-hydroxyphenyl)propanoate
5.3
-
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-methoxyphenyl)propanoate
5.8
-
-
Streptomyces globisporus
(2S,3R)-3-phenyloxirane-2-carboxylate
7.3
-
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-phenylpropanoate
11.6
-
-
Streptomyces globisporus
(2S,3R)-3-(4-fluorophenyl)oxirane-2-carboxylate
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3
-
-
Streptomyces globisporus
(2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylate
4.8
-
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-hydroxyphenyl)propanoate
5.3
-
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-methoxyphenyl)propanoate
5.8
-
-
Streptomyces globisporus
(2S,3R)-3-phenyloxirane-2-carboxylate
7.3
-
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-phenylpropanoate
11.6
-
-
Streptomyces globisporus
(2S,3R)-3-(4-fluorophenyl)oxirane-2-carboxylate
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(2S,3R)-3-(4-fluorophenyl)oxirane-2-carboxylate
-
Streptomyces globisporus
(2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylate
-
Streptomyces globisporus
(2S,3R)-3-phenyloxirane-2-carboxylate
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-hydroxyphenyl)propanoate
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-methoxyphenyl)propanoate
-
Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-phenylpropanoate
-
Streptomyces globisporus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-tyrosine
-
691277
Streptomyces globisporus
3-amino-3-(4-hydroxyphenyl)propanoate
-
-
-
?
Other publictions for EC 5.4.3.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747148
Attanayake
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3503-3514
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2
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1
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7
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1
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1
1
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15
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1
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7
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3
3
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-
747104
Walter
Mutation of aryl binding pock ...
Oryza sativa
Biochemistry
55
3497-3503
2016
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3
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7
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1
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4
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1
1
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4
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1
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7
1
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1
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1
1
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3
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7
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1
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1
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4
-
1
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-
7
1
-
-
-
-
1
1
-
6
6
748914
Yan
The tyrosine aminomutase TAM1 ...
Oryza sativa Japonica Group
Plant Cell
27
1265-1278
2015
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-
1
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1
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1
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-
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1
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6
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5
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1
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1
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1
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1
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1
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5
-
-
1
-
-
-
-
-
-
-
-
-
2
3
3
2
-
-
727685
Wanninayake
A bacterial tyrosine aminomuta ...
Chondromyces crocatus
J. Am. Chem. Soc.
135
11193-11204
2013
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1
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2
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1
1
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3
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1
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1
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1
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1
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3
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1
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1
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1
1
-
-
-
714481
Cooke
Probing the active site of MIO ...
Streptomyces globisporus
Biopolymers
93
802-810
2010
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1
1
4
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1
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1
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1
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1
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1
4
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1
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1
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714722
Wu
Engineering of an enantioselec ...
Chondromyces crocatus, Cupriavidus crocatus, Streptomyces globisporus
Chem. Commun. (Camb. )
46
8157-8159
2010
-
-
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6
-
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3
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3
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6
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3
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6
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3
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6
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3
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3
3
703203
Krug
Discovery of additional member ...
Chondromyces crocatus, Myxococcus fulvus Mx f65, Myxococcus sp. Mx-B0
ChemBioChem
10
741-750
2009
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3
-
12
-
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2
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3
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6
-
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3
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-
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4
-
3
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4
3
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3
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12
-
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2
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3
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3
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-
-
-
4
-
3
-
-
4
3
-
-
-
-
1
1
-
-
-
691277
Montavon
Design and characterization of ...
Streptomyces globisporus
Bioorg. Med. Chem. Lett.
18
3099-3102
2008
-
-
-
-
-
-
6
-
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1
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1
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6
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6
6
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1
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678295
Christianson
The structure of L-tyrosine 2, ...
Streptomyces globisporus
Biochemistry
46
7205-7214
2007
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1
1
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2
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1
1
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1
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-
650190
Christenson
Kinetic analysis of the 4-meth ...
Streptomyces globisporus
Biochemistry
42
12708-12718
2003
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1
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2
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3
4
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1
1
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1
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1
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6
1
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4
1
1
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1
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3
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4
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1
1
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1
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6
1
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4
1
1
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-
3406
Parry
-
Biosynthesis of amino acids. I ...
Brevibacillus brevis
J. Am. Chem. Soc.
102
836-837
1980
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1
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3405
Kurylo-Borowska
Biosynthesis of beta-tyrosine ...
Brevibacillus brevis
Biochim. Biophys. Acta
264
1-10
1972
-
-
-
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-
1
8
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1
1
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1
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1
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1
1
2
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1
1
2
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1
1
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1
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1
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1
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8
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1
1
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1
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1
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2
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2
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1
1
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