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Literature summary for 5.4.2.9 extracted from
- Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi (2003), J. Biol. Chem., 278, 22703-22708.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Trypanosoma cruzi |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
Phosphonopyruvate | 25°C, pH 8.0 | Trypanosoma cruzi |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Trypanosoma cruzi | 5829 | - |
| particle-bound | large granule fraction | Trypanosoma cruzi | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| Mg2+ | absolutely required | Trypanosoma cruzi | |
| Mg2+ | Km: 0.0084 mM | Trypanosoma cruzi | |
| Mg2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| Mn2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| additional information | no activation by Ca2+ | Trypanosoma cruzi | |
| Ni2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| Zn2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | Q8T8D9 | expressed during epimastygote, trypomastigote, mammalian amastigote stage | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 54 | - |
25°C, pH 8.0 | Trypanosoma cruzi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate | - |
Trypanosoma cruzi | 3-phosphonopyruvate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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