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Literature summary for 5.3.99.4 extracted from
- Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells (2010), J. Biol. Chem., 285, 11121-11128.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | prostacyclin synthase overexpression apparently protects insulin-producing cells against cytokine toxicity via suppression of endoplasmic reticulum and mitochondrial stress-mediated cell death pathways | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pcDNA3.1 vector for transfection of insulin-producing RINm5F cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U51605 | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prostacyclin synthase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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