Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Mus musculus |
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-phenyl-5-(1H-pyrazol-3-yl)thiazole | - |
Homo sapiens | |
2-phenyl-5-(1H-pyrazol-3-yl)thiazole | - |
Mus musculus | |
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid | - |
Homo sapiens | |
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid | - |
Mus musculus | |
5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide | - |
Homo sapiens | |
5-(3-cyanophenyl)-N-(diphenylmethyl)thiophene-2-carboxamide | - |
Homo sapiens | |
5-(3-cyanophenyl)-N-(diphenylmethyl)thiophene-2-carboxamide | - |
Mus musculus | |
5-(3-hydroxyphenyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
5-(3-hydroxyphenyl)thiophene-2-carboxylic acid | - |
Mus musculus | |
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid | - |
Homo sapiens | |
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid | - |
Mus musculus | |
HQL-79 | - |
Homo sapiens | |
HQL-79 | - |
Mus musculus | |
N-(1,6-diamino-1-oxohexan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1,6-diamino-1-oxohexan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2,3'-dihydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2,3'-dihydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-3-carboxamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-3-carboxamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(thiophen-2-yl)benzamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(thiophen-2-yl)benzamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide | - |
Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide | - |
Mus musculus | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide | selective H-PGDS inhibitor with low micromolar potency in the inhibition of the purified enzyme | Homo sapiens | |
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide | selective H-PGDS inhibitor with low micromolar potency in the inhibition of the purified enzyme | Mus musculus | |
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | - |
Homo sapiens | |
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | - |
Mus musculus | |
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | - |
Homo sapiens | |
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | - |
Mus musculus | |
N-(1-amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide | - |
Homo sapiens | |
N-(1-amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide | - |
Mus musculus | |
N-(1-amino-3-methyl-1-oxobutan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1-amino-3-methyl-1-oxobutan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-4-methyl-1-oxopentan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Homo sapiens | |
N-(1-amino-4-methyl-1-oxopentan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | - |
Mus musculus | |
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide | - |
Homo sapiens | |
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide | - |
Mus musculus | |
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | - |
Homo sapiens | |
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | - |
Mus musculus | |
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide | - |
Homo sapiens | |
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide | - |
Mus musculus | |
N-(diphenylmethyl)-2-phenyl-1,3-thiazole-4-carboxamide | - |
Homo sapiens | |
N-(diphenylmethyl)-2-phenyl-1,3-thiazole-4-carboxamide | - |
Mus musculus | |
N-(diphenylmethyl)-5-(1H-indol-4-yl)thiophene-2-carboxamide | - |
Homo sapiens | |
N-(diphenylmethyl)-5-(1H-indol-4-yl)thiophene-2-carboxamide | - |
Mus musculus | |
N-(diphenylmethyl)-5-phenylthiophene-2-carboxamide | - |
Homo sapiens | |
N-(diphenylmethyl)-5-phenylthiophene-2-carboxamide | - |
Mus musculus | |
N-(diphenylmethyl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide | - |
Homo sapiens | |
N-(diphenylmethyl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide | - |
Mus musculus | |
N-(diphenylmethyl)biphenyl-4-carboxamide | - |
Homo sapiens | |
N-(diphenylmethyl)biphenyl-4-carboxamide | - |
Mus musculus | |
N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide | low micromolar potency in the inhibition of the purified enzyme | Homo sapiens | |
N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)phenyl]-3-phenyl-1,2-thiazole-5-carboxamide | - |
Homo sapiens | |
N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)phenyl]-3-phenyl-1,2-thiazole-5-carboxamide | - |
Mus musculus | |
phenyl(thiophen-2-yl)methanone | - |
Homo sapiens | |
phenyl(thiophen-2-yl)methanone | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
GST-Prep column chromatography | Mus musculus |
GST-Prep column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow-derived macrophage | primary cell | Mus musculus | - |
MEG-01S cell | - |
Homo sapiens | - |
primary bone marrow-derived macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin D2 | - |
? | |
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H-PGDS | - |
Mus musculus |
H-PGDS | - |
Homo sapiens |
hematopoietic prostaglandin D2 synthase | - |
Mus musculus |
hematopoietic prostaglandin D2 synthase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | required | Mus musculus | |
glutathione | required | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0007 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | 2-phenyl-5-(1H-pyrazol-3-yl)thiazole | |
0.0007 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide | |
0.001 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | |
0.0012 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide | |
0.0013 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | |
0.0014 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | 4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid | |
0.0019 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | 5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide | |
0.0021 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | |
0.0037 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide | |
0.0038 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | HQL-79 | |
0.0046 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide | |
0.0071 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide | |
0.008 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide | |
0.0108 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide | |
0.0128 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | phenyl(thiophen-2-yl)methanone | |
0.023 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | 5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid | |
0.0248 | - |
in 0.1 M Tris-HCl, pH 8.0, at 25°C | Homo sapiens | N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide |