Literature summary for 5.3.3.21 extracted from

He, X.; Shoukry, K.; Chu, S.; Yang, J.; Sprecher, H.; Schulz, H.
Peroxisomes contain DELTA3,5,DELTA2,4-dienoyl-CoA isomerase and thus possess all enzymes required for the beta-oxidation of unsaturated fatty acids by a novel reductase-dependent pathway (1995), Biochem. Biophys. Res. Commun., 215, 15-22 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Nycodenz	-	Rattus norvegicus
Triton X-100	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-
peroxisome	-	Rattus norvegicus	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
a (3E,5Z)-alka-3,5-dienoyl-CoA	Rattus norvegicus	-	a (2E,4E)-alka-2,4-dienoyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,5,8,11,14-eicosapentaenoyl-CoA	22% and 13% activity in peroxisomes and mitochondria, respectively, compared to 3,5-octadienoyl-CoA	Rattus norvegicus	2,4,8,11,14-eicosapentaenoyl-CoA	-	?
3,5-octadienoyl-CoA	100% activity in peroxisomes and mitochondria	Rattus norvegicus	2,4-octadienoyl-CoA	-	?
3,5-tetradecadienoyl-CoA	29% and 36% activity in peroxisomes and mitochondria, respectively, compared to 3,5-octadienoyl-CoA	Rattus norvegicus	2,4-tetradecadienoyl-CoA	-	?
a (3E,5Z)-alka-3,5-dienoyl-CoA	-	Rattus norvegicus	a (2E,4E)-alka-2,4-dienoyl-CoA	-	?

Subunits

Subunits	Comment	Organism
?	x * 32000, mitochondrial enzyme, SDS-PAGE	Rattus norvegicus
?	x * 66000, peroxisomal enzyme, SDS-PAGE	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
DELTA3,5,DELTA2,4-dienoyl-CoA isomerase	-	Rattus norvegicus
dienoyl-CoA isomerase	-	Rattus norvegicus

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Release 2023.1 (January 2023)