Literature summary for 5.3.2.1 extracted from

Cho, Y.; Crichlow, G.V.; Vermeire, J.J.; Leng, L.; Du, X.; Hodsdon, M.E.; Bucala, R.; Cappello, M.; Gross, M.; Gaeta, F.; Johnson, K.; Lolis, E.J.
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast (2010), Proc. Natl. Acad. Sci. USA, 107, 11313-11318.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
MIF is cocrystallized with the R-isomer of AV1013 alone and with the substrate enol-(p-hydroxyphenyl)pyruvate	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester	-	Homo sapiens
AV1013	noncompetitive inhibitor of the p-hydroxyphenylpyruvate tautomerase activity of MIF	Homo sapiens
AV411	ibudilast, i.e. 3-isobutyryl-2-isopropylpyrazolo-[1,5-a]pyridine, noncompetitive inhibitor of the p-hydroxyphenylpyruvate tautomerase activity of MIF	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
enol-(p-hydroxyphenyl)pyruvate	-	Homo sapiens	keto-(p-hydroxyphenyl)pyruvate	-	?

Synonyms

Synonyms	Comment	Organism
Macrophage migration inhibitory factor	-	Homo sapiens
MIF	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0241	-	(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester	pH and temperature not specified in the publication	Homo sapiens
0.0749	-	AV411	pH and temperature not specified in the publication	Homo sapiens
0.309	-	AV1013	pH and temperature not specified in the publication	Homo sapiens

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Release 2023.1 (January 2023)