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Literature summary for 5.1.99.4 extracted from
- Differential expression of alpha-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance (2007), Hum. Pathol., 38, 850-856.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the enzyme is a biomarker overexpressed in prostate carcinomas and is associated with prostate cancer progression | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2S)-2-methylacyl-CoA | Homo sapiens | the enzyme plays an important role in peroxisomal beta-oxidation of branched-chain fatty acids from red meat and dairy products, the enzyme is a biomarker overexpressed in prostate carcinomas and is associated with prostate cancer progression | (2R)-2-methylacyl-CoA | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colorectal carcinoma cell | differential enzyme expression, overexpression and correlation with tumor pathologic features, immunohistochemic analysis, overview | Homo sapiens | - |
| hepatocarcinoma cell | primary carcinoma | Homo sapiens | - |
| prostate carcinoma cell | overexpression of the enzyme compared to healthy prostate gland | Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2S)-2-methylacyl-CoA | - |
Homo sapiens | (2R)-2-methylacyl-CoA | - |
r | |
| (2S)-2-methylacyl-CoA | the enzyme plays an important role in peroxisomal beta-oxidation of branched-chain fatty acids from red meat and dairy products, the enzyme is a biomarker overexpressed in prostate carcinomas and is associated with prostate cancer progression | Homo sapiens | (2R)-2-methylacyl-CoA | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-methylacyl coenzyme A racemase | - |
Homo sapiens |
| AMACR | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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