Literature summary for 5.1.3.38 extracted from

Burkhardt, S.; Jimenez de Baguees, M.P.; Liautard, J.P.; Koehler, S.
Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages (2005), Infect. Immun., 73, 6782-6790.

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Organism

Organism	UniProt	Comment	Textmining
Brucella suis	-	-	-
Brucella suis ATCC 23444	-	-	-

Synonyms

Synonyms	Comment	Organism
eryC	-	Brucella suis

General Information

General Information	Comment	Organism
physiological function	allelic exchange mutants in eryC of Brucella suis are erythritol sensitive in vitro with a minimal inhibitory concentration of 1 to 5 mM of erythritol. Their multiplication in macrophage-like cells is 50- to 90fold reduced, but complementation of the mutant restores wild-type levels of intracellular multiplication and the capacity to use erythritol as a sole carbon source. In vivo, the eryC mutant colonize the spleens of infected BALB/c mice to a significantly lower extent than the wild-type. eryC mutants that are in addition spontaneously erythritol tolerant nevertheless exhibit wild-type-like intramacrophagic and intramurine replication	Brucella suis

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Release 2023.1 (January 2023)