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Literature summary for 5.1.3.3 extracted from
- The enzymatically catalyzed mutarotation. The mechanism of action of mutarotase (aldose 1-epimerase) from Escherichia coli (1971), Eur. J. Biochem., 23, 489-496.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-O-Methylglycoside | - |
Escherichia coli |  |
| D-galactono-gamma-lactone | - |
Escherichia coli | |
| D-glucono-1,5-lactone | - |
Escherichia coli | |
| DL-glyceraldehyde | - |
Escherichia coli | |
| phlorizin | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.5 | - |
D-galactose | - |
Escherichia coli | |
| 13 | - |
D-fucose | - |
Escherichia coli | |
| 15 | - |
D-glucose | - |
Escherichia coli | |
| 23 | - |
D-xylose | - |
Escherichia coli | |
| 475 | - |
lactose | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| alpha-D-glucose = beta-D-glucose | the mechanism of the enzymatically catalyzed mutarotation is basically different from that of the nonenzymatically catalyzed mutarotation. The mutarotase acts primarily as a base catalyst. The enzymatically catalyzed mutarotation proceeds via the acyclic aldehyde form of the aldose | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-galactose | - |
Escherichia coli | beta-D-galactose | - |
? | |
| alpha-D-glucose | - |
Escherichia coli | beta-D-glucose | - |
? | |
| alpha-D-xylose | no specification of anomeric form | Escherichia coli | beta-D-xylose | - |
? | |
| beta-Lactose | no specification of anomeric form | Escherichia coli | alpha-Lactose | - |
? | |
| D-Fucose | - |
Escherichia coli | ? | - |
? | |
| D-Galactose | - |
Escherichia coli | ? | - |
? | |
| D-glucose | - |
Escherichia coli | ? | - |
? | |
| D-Xylose | - |
Escherichia coli | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
slow precipitation starts after a few minutes. High substrate concentrations stabilize | Escherichia coli |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Escherichia coli |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 2 | 10 | 5 min, stable | Escherichia coli |
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